Antisynthetase syndrome

Authors

  • David De Luca
  • Hernán Staiger
  • María Carolina Baztán
  • Paula Enz
  • Alicia Kowalczuk
  • Ricardo Galimberti

Keywords:

Antisynthetase syndrome, antisynthetase antibodies, anti-Jo1
Abstract Authors References How to Cite Downloads

Abstract

We report the case of a female adult with a history of interstitial pneumonia that debutes with systemic symptoms, skin rash, “mechanic's hands”, muscle weakness, and polyarthralgia. Through laboratory studies, histopathology of the skin, high resolution computed tomography and electromyogram, we arrived at the antisynthetase syndrome diagnosis. The antisynthetase syndrome is a rare autoimmune inflammatory of the myopathies group with high mortality and poor response to therapy, whose evolution depends on the lung involvement.

Author Biographies

David De Luca

Médico, jefe de residentes de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Hernán Staiger

Médico asociado, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

María Carolina Baztán

Médico asociado, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Paula Enz

Médico de planta, Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Alicia Kowalczuk

Médica, subjefa, Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Ricardo Galimberti

. Médico, jefe, Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

References

1. Hassan ML, Capecce A, Melloni ME, Saposnik M, Ruzzi I, Gramajo J, et al. Estudio retrospectivo de la dermatomiositis. Análisis de 40 casos de consulta en la División de Dermatología. Dermatol Argent. 2009;15:27-36.

2. Sontheimer RD, Costner MI. Dermatomyositis. In: Fitzpatrick TB, Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller A, et al. Fitzpatrick's Dermatology in General Medicine. 7th edition. New York: Mc Graw-Hill; 2008: 1536-53.

3. Bachmeyer C, Tillie-Leblond I, Lacert A, Cadranel J, Aractingi S. ‘Mechanic’s hands’: A misleading cutaneous sign of the antisynthetase syndrome. Br J Dermatol. 2007;156:192-4.

4. Leteurtre E, Hachulla E, Janin A, Hatron PY, Brouillard M, Devulder B. Manifestations vasculaires des dermatomyosites et polymyosites. Aspects cliniques, capillaroscopiques et histologiques. Rev Med Interne. 1994;15:800-7.

5. Dourmishev LA, Dourmishev AL, Schwartz RA. Dermatomyositis: An association of gingival telangiectases and anti Jo-1 antibody in the adult. Acta Dermatovenerol Alp. 2007;16:67-72.

6. Imbert-Masseau A, Hamidou M, Agard C, Grolleau JY, Chérin P. Antisynthetase syndrome. Joint Bone Spine. 2003;70:161-8.

7. Bielsa-Marsol I. Dermatomiositis. Reumatol Clin. 2009;5:216-22.

8. Imbert-Masseau A, Hamidou M, Agard C, Grolleau JY, Chérin P. Antisynthetase syndrome. Joint Bone Spine. 2003;70:161-8.

9. Limaye V, Cassidy J, Scott G, Roberts-Thomson P, Gillis D. AntiRo52 antibodies, antisynthetase antibodies, and antisynthetase syndrome. Clin Rheumatol. 2008;27:521-3

How to Cite

1.
De Luca D, Staiger H, Baztán MC, Enz P, Kowalczuk A, Galimberti R. Antisynthetase syndrome. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Aug. 9 [cited 2026 Mar. 17];20(4):381-4. Available from: https://revistaasocoldermaorgco.biteca.online/index.php/asocolderma/article/view/1001

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Published

2019-08-09

How to Cite

1.
De Luca D, Staiger H, Baztán MC, Enz P, Kowalczuk A, Galimberti R. Antisynthetase syndrome. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Aug. 9 [cited 2026 Mar. 17];20(4):381-4. Available from: https://revistaasocoldermaorgco.biteca.online/index.php/asocolderma/article/view/1001

Issue

Vol. 20 No. 4 (2012): October - December

Section

Case Report
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