A 52 years-old man with generalized and recurrent ulcers, ¿what is your diagnosis?
Keywords:
leprosy, lepromatous leprosy, necrosis, vasculitis.Abstract
Erythema nodosum leprosum, or type 2 reaction, is a type III hypersensitivity reaction. It is characterized by eruptions of painful nodules that last a few days or weeks and is generally associated with systemic involvement. It rarely occurs with the formation of necrotic ulcerated nodules. This variety has been called necrotic erythema nodosum leprosum due the important vasculonecrotic process that occurs. The necrotic erythema nodosum leprosum is a rare condition, occurring in severe type 2 leprosy reactions associated with high bacillary indexes, mainly in cases of longstanding multibacillar leprosy. It presents with significant cutaneous and systemic involvement. Clinical diagnosis is not easy, the necrotic lesions and the presence of ulcers, can cause confusion with other diseases.
Author Biographies
Ana María Téllez
Médica, residente de Dermatología, Fundación Universitaria Sánitas, Bogotá, D.C., Colombia; Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, D.C., Colombia
Gerzaín Rodríguez
Médico dermatopatólogo, consultor, Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, D.C., Colombia; profesor, Facultad de Medicina, Universidad de La Sabana, Chía, Cundinamarca
María Cristina Ronderos
Médica dermatóloga, Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, D.C., Colombia.
References
2. Rodríguez G, Pinto R. La Lepra. Imágenes y conceptos. Medellín: Editorial Universidad de Antioquia, Universidad de La Sabana; 2007.
3. Kamath S, Vaccaro SA, Rea TH, Ochoa MT. Recognizing and managing the immunologic reactions in leprosy. J Am Acad Dermatol. 2014;71:1-9.
4. Rodríguez G, Abaúnza MC, Vargas EJ, López F. La lepra y el testículo. Biomédica. 2012;32:13-22.
5. Rodríguez G. Adenopatías generalizadas como presentación de la reacción leprótica tipo 2. Biomédica. 2003;23:373-87.
6. Kahawita IP, Lockwood DNJ. Towards understanding the pathology of erythema nodosum leprosum. Trans R Soc Trop Med Hyg. 2008;102:329-37.
7. Fogagnolo L, de Souza EM, Cintra ML, Velho PE. Vasculonecrotic reactions in leprosy. Braz J Infect Dis. 2007;11:378-82.
8. Benard G, Sakai-Valente NY, Bianconcini Trindade MA. Concomitant Lucio´s phenomenon and erythema nodosum in a leprosy patient: Clues for their distinct pathogeneses. Am J Dermatopathol. 2009;31:288-92.
9. Rodríguez G, Berrío J, Sarmiento L. La lepra y el riñón. Biomédica. 1999;19;45-55.
10. Vijendran P, Verma R, Vasudevan B, Mitra D, Badad A, Neema S. Rare atypical presentations in type 2 lepra reaction: A case series. Int J Dermatol. 2014;53:323-6.
11. Ramesh V, Pahwa M. Some unusual type 2 reactions in leprosy. Int J Dermatol. 2010;53:172-5.
12. Ranugha P, Chandrashekar L, Kumari R, Thappa DM, Badhe B. Is it Lucio phenomenon or necrotic erythema nodosum leprosum? Indian J Dermatol. 2013;58:160.
13. Pandhi D, Metha S, Agrawal SA. Erythema nodosum leprosum necroticans in a child. An unsual manifestation. Int J Lepr Other Mycobact Dis. 2005;73:122-6.
14. Tourlaki A, Marzano AV, Gianotti R, Fiallo P, Nunzi E. Necrotic erythema nodosum leprosum as the first manifestation of borderline lepromatous leprosy. Arch Dermatol. 2008;144:818-20.
15. Vandana Mehta R, Balachandran C. Necrotic erythema nodosum leprosum (NENL). Dermatol Online J. 2006;12:12.
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |



