Discoid lupus in children and adults: ¿What is the difference?
Keywords:
Discoid lupus erythematosus, systemic lupus erythematosus.Abstract
Discoid lupus in children is a rare disease; it differs from lupus in the adult population in the increased risk of progression to systemic erythematosus lupus according to reports and case series published in the worldwide literature. The main differential diagnosis is neonatal lupus that occurs earlier in life; it is not associated with residual scar lesions and is frequently associated with cardiac involvement which resultsin high risk of mortality. The case of a 3 years old female patient with discoid lupus in the face, without signs or symptoms of systemic erythematosus lupus, with adequate response to treatment with topical calcineurin inhibitors and steroids is presented. Studies are needed with larger numbers of patients and comparison groups to evaluate the sociodemographic and clinical characteristics of this disease in children.
Author Biographies
Alba Patricia Ferrín
Médica, residente de Dermatología, Universidad de Antioquia, Medellín, Colombia
Ana María Muñoz
Médica, M.Sc. en Epidemiología Clínica, residente de Dermatología, Universidad Pontificia Bolivariana, Medellín, Colombia
María Isabel Parga
Médica dermatóloga; docente adscrita, Universidad de Antioquia, Medellín, Colombia.
References
2. Okon LG, Werth VP. Cutaneous lupus erythematosus: Diagnosis and treatment. Best Pract Res Clin Rheumatol. 2013;27:391-404.
3. Cherif F, Mebazaa A, Mokni M, El Euch D, Azaiz MI, Dhahri AB. Childhood discoid lupus erythematosus: A Tunisian retrospective study of 16 cases. Pediatr Dermatol. 2003;20:295-8.
4. Sampaio MC, de Oliveira ZN, Machado MC, dos Reis VM, Vilela MA. Discoid lupus erythematosus in children--a retrospective study of 34 patients. Pediatr Dermatol. 2008;25:163-7.
5. Moisés-Alfaro C, Berrón-Pérez R, Carrasco-Daza D, Gutiérrez-Castrellón P, Ruiz-Maldonado R. Discoid lupus erythematosus in children: Clinical, histopathologic, and follow-up features in 27 cases. Pediatr Dermatol. 2003;20:103-7.
6. Arkin LM, Ansell L, Rademaker A, Curran ML, Miller ML, Wagner A, et al. The natural history of pediatric-onset discoid lupus erythematosus. J Am Acad Dermatol. 2015;72:628-33.
7. Del Boz J, Martín T, Samaniego E, Vera A, Sanz A, Crespo V. Childhood discoid lupus in identical twins. Pediatr Dermatol. 2008;25:648-9.
8. Kawachi Y, Taguchi S, Fujisawa Y, Furuta J, Nakamura Y, Ishii Y, et al. Linear childhood discoid lupus erythematosus following the lines of Blaschko: Successfully treated with topical tacrolimus. Pediatr Dermatol. 2011;28:205-7.
9. Piras D, Cottoni F. Mucosal involvement in childhood discoid lupus erythematosus. J Eur Acad Dermatol Venereol. 2003;17:731-2.
10. Wimmershoff MB, Hohenleutner U, Landthaler M. Discoid lupus erythematosus and lupus profundus in childhood: A report of two cases. Pediatr Dermatol. 2003;20:140-5.
11. Kerstan A, Goebeler M, Schmidt E, Bröcker EB, Schön MP. Lupus erythematosus profundus in an 8-year-old child. J Eur Acad Dermatol Venereol. 2007;21:132-3.
12. George PM, Hood AF, Rest EB. Histopathology and immunofluorescence of discoid lupus erythematosus in children. Pediatr Dermatol. 1996;13:269-73.
13. George PM, Tunnessen WW Jr. Childhood discoid lupus erythematosus. Arch Dermatol. 1993;129:613-7.
14. Buyon JP. Neonatal lupus. In: Up to date, oct 2014, Lehman T, TePas E (Ed). (Accessed on January 16, 2016).
15. Miettunen PM, Bruecks A, Remington T. Dramatic response of scarring scalp discoid lupus erythematosus (DLE) to intravenous methylprednisolone, oral corticosteroids, and hydroxychloroquine in a 5-year-old child. Pediatr Dermatol. 2009;26:338-41.
How to Cite
Downloads
Downloads
Published
How to Cite
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
