Benzoyl peroxide associated with erythromycin in the management of progressive macular hypomelanosis of the trunk.
Keywords:
Hypopigmentation, Propionibacterium acnes, erythromycin, benzoyl peroxideAbstract
A 23 year old female patient, racially mixed, with a 10 year history of hypopigmented asymptomatic spots in the lower back, who had received multiple treatments without any improvement. The clinical, mycological and histopathological findings made the diagnosis of progressive macular hypomelanosis of the trunk. She received a topical combination of benzoyl peroxide and erythromycin with resolution of the lesions. This case is an example of an alternative treatment.
Author Biographies
Lucy García
Dermatóloga, docente de Dermatología, Universidad del Valle, Cali, Colombia.
Liliana Muñoz
Dermatopatóloga, Universidad del Valle, Cali, Colombia
Joaquin Benavides
Residente de Dermatología, Universidad del Valle, Cali, Colombia.
References
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2. Relyveld GN, Menke HE, Westerhof W. Progresive macular hypomelanosis an overview. Am J Clin Dermatol. 2007;8:13-9.
3. Westerhof W, Relyveld GN, Kingswijk MM, de Man P, Menke HE. Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. Arch Dermatol. 2004;140:210-4.
4. Perman M, Sheth P, Lucky AW. Progressive macular hypomelanosis in a 16-year old. Pediatr Dermatol. 2008;25:63-5.
5. Borelli D. Cutis trunci variata: nueva genodermatosis. Med Cutan Ibero Lat Am.1987;15:317-9.
6. Kumarasinghe SPW, Tan SH, Thng S, Thamboo TP, Liang S, Lee YS. Progressive macular hypomelanosis in Singapore: a clinico-pathological study. Int J Dermatol. 2006;45:737-42.
7. Relyvelt GN, Dingemans KP, Menke HE, Bos JD, Westerhof W. Ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production. J Eur Acad Dermatol Venereol. 2008;22:568-74.
8. Mollet I, Ongenae K, Naeyaert JM. Origin, clinical presentation, and diagnosis of hypomelanotic skin disorders. Dermatol Clin. 2007;25:363-71.
9. Relyveld GN, Kingswijk MM, Reitsma JB, Menke HE, Bos JD, Westerhof W. Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: A randomized study. J Am Acad Dermatol. 2006;55:836-43.
10. Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs 2004;64:2389-97.
11. Basak PY, Gultekin F, Kiline I, Delibas N. The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defense system in papulopustular acne. Eur J Dermatol. 2002;12:53-7.
12. Eady EA, Bojar RA, Jones CE, Cove J H; Holland K T; Cunliffe W J. The effects of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythro-mycin-resistant propionibacteria. Br J Dermatol. 1996;134:107-13.
2. Relyveld GN, Menke HE, Westerhof W. Progresive macular hypomelanosis an overview. Am J Clin Dermatol. 2007;8:13-9.
3. Westerhof W, Relyveld GN, Kingswijk MM, de Man P, Menke HE. Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. Arch Dermatol. 2004;140:210-4.
4. Perman M, Sheth P, Lucky AW. Progressive macular hypomelanosis in a 16-year old. Pediatr Dermatol. 2008;25:63-5.
5. Borelli D. Cutis trunci variata: nueva genodermatosis. Med Cutan Ibero Lat Am.1987;15:317-9.
6. Kumarasinghe SPW, Tan SH, Thng S, Thamboo TP, Liang S, Lee YS. Progressive macular hypomelanosis in Singapore: a clinico-pathological study. Int J Dermatol. 2006;45:737-42.
7. Relyvelt GN, Dingemans KP, Menke HE, Bos JD, Westerhof W. Ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production. J Eur Acad Dermatol Venereol. 2008;22:568-74.
8. Mollet I, Ongenae K, Naeyaert JM. Origin, clinical presentation, and diagnosis of hypomelanotic skin disorders. Dermatol Clin. 2007;25:363-71.
9. Relyveld GN, Kingswijk MM, Reitsma JB, Menke HE, Bos JD, Westerhof W. Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: A randomized study. J Am Acad Dermatol. 2006;55:836-43.
10. Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs 2004;64:2389-97.
11. Basak PY, Gultekin F, Kiline I, Delibas N. The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defense system in papulopustular acne. Eur J Dermatol. 2002;12:53-7.
12. Eady EA, Bojar RA, Jones CE, Cove J H; Holland K T; Cunliffe W J. The effects of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythro-mycin-resistant propionibacteria. Br J Dermatol. 1996;134:107-13.
How to Cite
1.
García L, Muñoz L, Benavides J. Benzoyl peroxide associated with erythromycin in the management of progressive macular hypomelanosis of the trunk. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 14 [cited 2026 Mar. 17];18(1):43-5. Available from: https://revistaasocoldermaorgco.biteca.online/index.php/asocolderma/article/view/190
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Published
2019-02-14
How to Cite
1.
García L, Muñoz L, Benavides J. Benzoyl peroxide associated with erythromycin in the management of progressive macular hypomelanosis of the trunk. rev. asoc. colomb. dermatol. cir. dematol. [Internet]. 2019 Feb. 14 [cited 2026 Mar. 17];18(1):43-5. Available from: https://revistaasocoldermaorgco.biteca.online/index.php/asocolderma/article/view/190
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Case Report
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