Histopathological patterns identified in skin biopsies with tegumentary leishmaniasis in Colombia.
DOI:
https://doi.org/10.29176/2590843X.2070Keywords:
Granuloma, Hematoxylin-eosin, Inflammation, Leishmania, Lymphoplasmacytic infiltrate, Mucocutaneous leishmaniasis, Parasite load, UlcerAbstract
Introduction: Tegumentary leishmaniasis (TL) is a neglected disease that affects the skin and mucous membranes. Its detection poses a challenge due to the lack of a gold standard for diagnosis.
Objective: To describe the histopathological patterns associated with a group of samples from patients with tegumentary leishmaniasis.
Methods: This descriptive study was conducted through histopathological evaluation using hematoxylin-eosin staining on 43 paraffin-embedded samples of chronic tegumentary leishmaniasis, categorized into three groups: moderate to high parasite load (n=15), low load (n=15), and chronic granulomatous inflammation (n=13).
Results: Epidermal hyperplasia was observed in 34.9% of cases, and ulcers were present in 62.8% of cases. A predominant lymphoplasmacytic infiltrate was found in 67.4% of samples, while a histiocytic infiltrate was observed in 90.7% of samples. In samples with no detectable parasite load, the histiocytic infiltrate was present in 94.8% of cases. In samples with low parasite load, the histiocytic infiltrate was significant in 55.5% of cases, and 86.6% of the samples with moderate to high parasite load exhibited this histopathological pattern.
Conclusions: Lymphoplasmacytic and histiocytic infiltrates are consistent histopathological patterns, even in samples with low or absent parasite load.
Author Biographies
Lucero Katherine Aristizábal-Parra , Universidad CES, Medellín, Colombia
Instituto Colombiano de Medicina Tropical, Universidad CES, Medellín, Colombia.
Juan Pablo Ospina-Gómez, Universidad de Antioquia, Medellín, Colombia
Centro de Investigaciones en Dermatología - CIDERM, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Héctor Serrano-Coll, Universidad CES, Medellín, Colombia
Instituto Colombiano de Medicina Tropical, Universidad CES, Medellín, Colombia.
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Copyright (c) 2025 Lucero Katherine Aristizábal-Parra , Juan Pablo Ospina-Gómez, Héctor Serrano-Coll
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