Drug-induced toxic epidermal necrolysis in a pediatric patient: case report and literature review
DOI:
https://doi.org/10.29176/30284163.2077Keywords:
Antibiotic, Childhood, Epidermal necrolyses toxic, Stevens-Johnson syndromeAbstract
Toxicodermias are adverse reactions in the skin caused by medications. Their diagnosis is based on the clinical history and the findings on physical examination, considering that a single medication can present different cutaneous manifestations. Toxicodermias can be classified into non-severe and severe, such as angioedema, Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), among others, which are differentiated by their clinical manifestations, possible sequelae, as well as by their latency period. Mortality varies according to each clinical presentation: for SJS it is 5%, and for TEN it is 30%. The early presentation of this case makes it interesting and may give rise to future investigations of other cases with atypical presentation. Knowing the possible triggers of toxicodermias in pediatrics helps physicians not to omit or minimize the risk of this adverse reaction, regardless of its low incidence.
Author Biographies
Laura Zulema Mosquera Vilelgas, Military University Nueva Granada
Médico general, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia.
Daniela Guevara-Parra, Hospital Universitario Clínica San Rafael, Bogotá, Colombia
Médico general, Facultad de Medicina, Universidad Militar Nueva Granada. Residente de Pediatría, Facultad de Medicina Universidad Militar Nueva Granada. Hospital Universitario Clínica San Rafael, Bogotá, Colombia.
Alejandra Granados-Betancur, Fundación Universitaria Visión de las Américas, Pereira, Colombia
Médico general, Fundación Universitaria Visión de las Américas, Pereira, Colombia.
Dilia Pinzón-Sánchez, Hospital Universitario Clínica San Rafael, Bogotá, Colombia
Especialista en Pediatría, Facultad de Medicina, Universidad Militar Nueva Granada. Pediatra, Hospital Universitario Clínica San Rafael, Bogotá, Colombia.
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