Juvenile pemphigus vulgaris. About a case
DOI:
https://doi.org/10.29176/2590843X.1838Keywords:
Pemphigus, blisters, autoimmuneAbstract
Pemphigus vulgaris is a blistering disease of autoimmune origin, which affects skin and mucous membranes, and is mediated by autoantigen-directed anti-IgG autoantibodies, Dsg 1 and 3 present in keratinocytes. Causing loss of cell adhesion, just above the basal layer, forming intraepidermal blisters. The case of a 14-year-old adolescent with no significant history is described, who presented bilateral and symmetrical generalized dermatosis on the oral mucosa, characterized by flaccid blisters, some exulcerated and hematocysts on the surface, positive Nikolsky sign, painful for 1 month of evolution. A skin biopsy was performed, which he reported; suprabasal intraepidemic acantholytic blister and mild superficial perivascular lymphocytic inflammatory infiltrate in the dermis. Treatment was started with Wonder's magistral solution, topical and systemic steroids and immunosuppressants with a good response. A case is reported because it is an infrequent disease in adolescence, I feel its peak of appearance between the fourth and sixth decade of life.
Author Biographies
Mary Lisbeth Soto Pernia, University of Carabobo
Médico residente, segundo año del Posgrado de Dermatología, Universidad de Carabobo, Ciudad Hospitalaria “Dr. Enrique Tejera”, Valencia, Estado Carabobo, Valencia, Venezuela.
María Manzanero, University of Carabobo
Médico residente, segundo año del Posgrado de Dermatología, Universidad de Carabobo, Ciudad Hospitalaria “Dr. Enrique Tejera”, Valencia, Estado Carabobo, Venezuela.
Ismar Marte, University of Carabobo
Médico residente, tercer año del Posgrado de Dermatología, Universidad de Carabobo, Ciudad Hospitalaria “Dr. Enrique Tejera”, Valencia, Estado Carabobo, Venezuela.
Sandra Carlina Vivas Toro, University of Carabobo
Médico internista, dermatóloga. Magíster en Investigación Educativa. Jefa, Servicio de Dermatología, Universidad de Carabobo, Ciudad Hospitalaria “Dr. Enrique Tejera”. Coordinadora, programa de Posgrado de Dermatología. Miembro, Sociedad Venezolana de Dermatología; Sociedad Internacional de la Dermatoscopia.
References
Bellelli AG, Mantero NM, Rueda L, Navacchia D, Cao G, Lillo L De, et al. Pénfigo vulgar de la infancia, a propósito de un caso. Arch Argent Pediatr. 2016;114(6):457-60.
Cura MJ, Torre AC, Cueto Sarmiento KY, Bollea Garlatti ML, Riganti J, Puga MC, et al. Pemphigus Vulgaris: A Retrospective Cohort Study of Clinical Features, Treatments, and Outcomes. Actas Dermosifiliogr. 2020;111(5):398-407. https://doi.org/10.1016/j.ad.2019.10.004
Ocampo ÓJV, Velásquez-Lopera MM. Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo. Iatreia. 2011;24(3):272-86.
Chanussot-Deprez C, Vega Memije ME, Mosqueda-Taylor A, Barrezueta-Chea S, Hernández-Delgado L, Vázquez-Zavala G. Pénfigo vulgar en una niña de 14 años. Med Cutan Iber Lat Am. 2007;35:285-9.
Chavolla TMR, Memije MEV, Taylor AM, Gamboa ELR. Pénfigo vulgar en pacientes menores de 30 años. Informe del manejo clínico y terapéutico de 17 casos. Dermatol Cosmet Med Quir. 2008;6(2):87-92.
Nayak V, Kini R, Rao PK, Shetty U. Pemphigus vulgaris. BMJ Case Rep. 2020;13(5):1-2. https://doi.org/10.1136/bcr-2020-235410
Tani N, Sugita K, Ishii N, Wakumoto K, Hashimoto T, Yamamoto O. Juvenile pemphigus vulgaris manifesting as vegetating skin lesions. Clin Exp Dermatol. 2019;44(5):559-61. https://doi.org/10.1111/ced.13796
Kong HH, Prose NS, Ware RE, Hall RP. Successful treatment of refractory childhood pemphigus vulgaris with antiCD20 monoclonal antibody (rituximab). Pediatr Dermatol. 2005;22(5):461-4.
O’Shea JJ, Kontzias A, Yamaoka K, Tanaka Y, Laurence A. Janus kinase inhibitors in autoimmune diseases. Ann Rheum Dis. 2013;72 Suppl 2(0 2):ii111-5. https://doi.org/10.1136/annrheumdis-2012-202576
Youssef S, Gallitano S, Bordone LA. Two cases of bullous pemphigoid effectively treated with oral tofacitinib. JAAD Case Rep. 2022;32:77-80. https://doi.org/10.1016/j.jdcr.2022.10.028
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Copyright (c) 2024 Mary Lisbeth Soto Pernia, María Manzanero, Ismar Marte, Sandra Carlina Vivas Toro
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