Subcorneal pustular dermatosis successfully treated with colchicine
DOI:
https://doi.org/10.29176/2590843X.1980Keywords:
Colchicine, Dermatology, Sneddon-Wilkinson diseaseAbstract
The subcorneal pustular dermatosis, also known as Sneddon-Wilkinson disease, is a rare, benign, although recurrent condition classified within the group of neutrophilic dermatoses. Its pathogenesis remains unclear. Clinically, pustules appear on the trunk and intertriginous areas, rarely on acral locations. Histologically, subcorneal collections of neutrophils form pustules. While dapsone remains the treatment of choice, this case report highlights a successful alternative treatment using colchicine, a well-established second-line drug, although multiple treatments have been described today, among the most recent, for example, adalimumab, a monoclonal antibody against tumor necrosis factor α (TNF-α). Colchicine is accessible, safe, and effective, and should be considered among the first lines of treatment.
Author Biographies
Bruny Carolina Llamas Castellanos, Universidad de Cartagena, Colombia
Especialización en Dermatología, Facultad de Medicina, Universidad de Cartagena, Colombia.
Stephanie Hernández Buitrado, Universidad de Cartagena, Colombia.
Especialización en Dermatología, Facultad de Medicina, Universidad de Cartagena, Colombia.
Francisco Camacho, Universidad de Cartagena, Colombia
Departamento de Dermatología, Facultad de Medicina, Universidad de Cartagena, Colombia.
Sandra Viviana Meneses-Gaviria, Universidad de Cartagena, Colombia
Especialización en Dermatología, Facultad de Medicina, Universidad de Cartagena, Colombia.
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Copyright (c) 2025 Bruny Carolina Llamas Castellanos, Stephanie Hernández Buitrado, Francisco Camacho, Sandra Viviana Meneses-Gaviria
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
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