Verruciform epidermodysplasia and colombian contributions: a historical perspective
DOI:
https://doi.org/10.29176/2590843X.2014Keywords:
Epidermodysplasia verruciformis, human papillomavirus, squamous cell carcinoma, ColombiaAbstract
Introduction: Epidermodysplasia verruciformis (EV) is a genodermatosis associated with an increased risk of squamous cell carcinoma (SCC) due to the abnormal susceptibility to human papillomavirus (HPV) infection.1
Materials and methods: A search was performed in Medline, Lilacs, and in the personal library of Dr. Gerzaín Rodriguez. We found documents and photographs, most of them from the 1970s, of the research carried out by doctors Luis Alfredo Rueda and Gerzain Rodriguez in a family from Viracachá, Boyacá. Results: In the 1970s, research carried out in Colombia helped to elucidate aspects that improved the understanding of EV, elements that served to clarify the relationship between skin and mucosal cancer and HPV 2.2,3
Discussion: The advances of the last two decades of the 20th century allowed us to elucidate the carcinogenic potential inherent to HPV in the cervix, long before it was suspected of being an infectious agent. Its carcinogenic capacity was demonstrated in epidermodysplasia verruciformis (EV), and these findings contributed to the understanding of other oncogenic associations.4,5,6
Conclusions: Papillomaviruses have several genotypes that can cause cancer in different parts of the body. Its carcinogenic capacity was first demonstrated in epidermodysplasia verruciformis (EV), and these findings were extended to cervical cancer, leading to the development of preventive vaccines. Colombian contributions to EV research have been key to this scientific advance. This article is a recognition of those efforts.
Author Biographies
Bladimir Rodriguez-Lechtig, Universidad El Bosque. Bogotá, Colombia
Residente de dermatología. Universidad El Bosque. Bogotá, Colombia.
Marlon Yesid Barrera, Universidad El Bosque, Bogotá, Colombia
Residente, Programa de Dermatología, Universidad El Bosque, Bogotá, Colombia.
Juliana Pinzón-Luna, Universidad El Bosque. Bogotá, Colombia
Residente de dermatología. Universidad El Bosque. Bogotá, Colombia.
Ana M. Sarmiento-Ruiz, Universidad El Bosque. Bogotá, Colombia
Residente de dermatología. Universidad El Bosque. Bogotá, Colombia.
Sebastián Gil-Quiñones, Universidad El Bosque. Bogotá, Colombia
Dermatólogo, Profesor de Dermatología. Universidad El Bosque. Bogotá, Colombia Grupo de Investigación. Dermatología Clínica e Infecciosa. Universidad El Bosque. Bogotá, Colombia.
Adriana Motta, Universidad El Bosque, Bogotá, Colombia
Dermatóloga. Docente, Posgrado de Dermatología, Universidad El Bosque. Grupo de Investigación, Dermatología Clínica e Infecciosa, Universidad El Bosque, Bogotá, Colombia.
References
Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet. 2002;32(4):579-581.
Rueda LA, Rodríguez G. Verrugas humanas por virus Papova. Correlación clínica, histológica y ultrastructural. Med Cutan lber Lat Am 1976; 2: 113-136.
Kremsdorf D, Favre M, Jablonska S, et al. Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis. J Virol. 1984;52(3):1013-1018.
Rodríguez, G. Contribuciones del profesor Luis Alfredo Rueda al estudio de la epidermodisplasia verruciforme. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica. 2000; 8(1): 10-14.
Bosch FX, Muñoz N. The viral etiology of cervical cancer. Virus Res. 2002;89(2):183-190.
Rodriguez, G.. Los papilomavirus, el virus del sida y los premios nobel de medicina y fisiología, 2008. Cuadernos de Medicina en investigación y salud. 2008; 2(2): 74, 79.
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Copyright (c) 2025 Bladimir Rodriguez-Lechtig, Marlon Yesid Barrera, Juliana Pinzón-Luna, Ana M. Sarmiento-Ruiz, Sebastián Gil-Quiñones, Adriana Motta, Gerzain Rodriguez Toro
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
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